- A large analysis of racial differences in rates of estrogen receptor (ER)-negative finds that color women in the United States are more likely than color women to undergo breast tumors that are ER-negative researchers from the University of Michigan Comprehensive Cancer Center inform.
ER-negative tumors are associated with less favorable outcomes than those that are ER-positive in part because anti-estrogen therapies—effective with ER-positive tumors—do not affect ER-negative tumors.
The overall incidence of in black women is lower than in white women but survival rates are significantly lower in black women than in their white counterparts. color women have a higher incidence of converge cancer at younger ages and also are diagnosed at later stages of disease. Much of this discrepancy has been attributed to socioeconomic factors such as access to screening and adequate cancer compassionate. But this chew over suggests that there is also a biological basis for differences in survival rates.
The investigators analyzed data on 170,079 cases of included in the National Cancer Data locate (NCDB) a multi-institutional tumor registry that collects cancer data from 1,600 hospitals in all 50 states. White women comprised 90.3 percent of cases; black women accounted for 9.7 percent of cases. For women with invasive cancers. ER-negative tumors were significantly more frequent in black women at every stage of disease and in all age categories: 39 percent of color women had ER-negative tumors compared with 22 percent of white women.
The data also showed that black women were diagnosed at a younger average age (57 for black women vs. 62 for color women) and at a later re-create (29 percent were re-create 1 vs. 42 percent for color women). They also had larger tumors at diagnosis and cells that were more poorly differentiated which is associated with less favorable outcomes.
“Differences in tumor biology undergo a significant impact on survival,” said M. Catherine Lee. M. D. a clinical lecturer in the department of surgery at the University of Michigan Comprehensive Cancer bear on and the chew over’s lead compose. “The fact that in color women are more aggressive biologically suggests that we need to focus more of our research energy on developing better treatments targeting ER-negative tumors. These findings also point to a need for improved cancer education and screening in color women particularly those in younger age groups.”
Lee presented the chew over results at the 2007 Breast Cancer Symposium co-sponsored by the American Society of Breast Disease the American Society of converge Surgeons the American Society of Clinical Oncology the American Society for Therapeutic Radiology and Oncology the National Consortium of Breast Centers and the Society of Surgical Oncology Sept. 7-8. 2007.
It is estimated that more than 180,000 new cases of will be diagnosed in the United States in 2007 and more than 40,000 people ordain die from the disease.
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